fbs is a cross-platform PyQt5 packaging system which supports building desktop applications for Windows, Mac and Linux (Ubuntu, Fedora and Arch). Built on top of PyInstaller it wraps some of the rough edges and defines a standard project structure which allows the build process to be entirely automated. The included resource API is particularly useful, simplifying the handling of external data files, images or third-party libraries — a common pain point when bundling apps.
The first step in creating desktop applications with PyQt is getting a window to show up on your desktop. Thankfully, with PyQt that is pretty simple.